Ascites development and peritoneal dissemination are critical problems in patients with advanced ovarian cancer. via the increased vascular permeability effect. The deregulation of E\cadherin expression might be involved in the peritoneal dissemination. These molecules are important for the formation of specific features of advanced ovarian cancer. Ovarian cancer cell lines that had different gene expression patterns produced nude mouse human ovarian cancer models with different characteristics. strong class=”kwd-title” Keywords: Vascular endothelial growth factor, E\Cadherin, Ovarian cancer, Ascites, Dissemination Recommendations 1. ) Cancer Statistics in Japan databases ( http://www.ncc.go.jp/jp/statistics/2001/tables ). 2. ) Folkman J.What is the evidence that Pitavastatin calcium ic50 tumors are angiogenesis dependent ? J. Natl. Cancer Inst. , 82 , 4 C 6 ( 1990. ). [PubMed] [Google Scholar] 3. ) Liotta L. A. , Steeg P. S. and Stetler S. W.Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation . Cell , 64 , 327 C 336 ( 1991. ). [PubMed] [Google Scholar] 4. ) Weidner N. , Semple J. P. , Welch W. R. and Folkman J.Tumor angiogenesis and metastasiscorrelation in invasive breast carcinoma . N. Engl. J. Med. , 324 , 1 C 8 ( 1991. ). [PubMed] [Google Scholar] 5. ) Dvorak H. F. , Brown L. F. , Detmar M. and Dvorak A. M.Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis . Am. J. Pathol. , 146 , 1029 C 1039 ( 1995. ). [PMC free article] [PubMed] [Google Scholar] 6. ) Berse B. , Brown L. F. , Van de Water L. , Dvorak H. F. and Senger D. R.Vascular permeability factor (vascular endothelial growth factor) gene is usually expressed differentially in normal tissues, macrophages, and tumors . Mol. Biol. Cell , 3 , 211 C 220 ( 1992. ). [PMC free article] [PubMed] [Google Scholar] 7. ) Yeo K. T. , Wang H. H. , Nagy J. A. , Sioussat T. M. , Ledbetter S. Rabbit Polyclonal to SIN3B R. , Hoogewerf A. J. , Zhou Y. , Masse E. M. , Senger D. R. , Dvorak H. F. and Yeo T. K.Vascular permeability factor (vascular endothelial growth factor) in guinea pig and human tumor and inflammatory effusions . Cancer Res. , 53 , 2912 C 2918 ( 1993. ). [PubMed] [Google Scholar] 8. ) Luo J. C. , Yamaguchi S. , Shinkai A. , Shitara K. and Shibuya M.Significant expression of vascular endothelial growth factor/vascular permeability factor in mouse ascites tumors . Cancer Res. , 58 , 2652 C 2660 ( 1998. ). [PubMed] [Google Scholar] 9. ) Senger D. R. , Galli S. J. , Dvorak A. M. , Perruzzi C. A. , Harvey V. S. and Dvorak H. F.Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites liquid . Research , 219 , 983 C 985 ( 1983. ). [PubMed] [Google Scholar] 10. ) Nagy J. A. , Masse E. M. , Herzberg K. T. , Meyers M. S. , Yeo K. T. , Yeo T. K. , Sioussat T. M. and Dvorak H. F.Pathogenesis of ascites tumor development: vascular permeability aspect, vascular hyperpermeability, and ascites liquid accumulation . Cancers Res. , 55 , 360 C 368 ( 1995. ). [PubMed] [Google Scholar] 11. ) Sommers C. L. , Walker J. D. , Heckford S. E. , Worland P. , Valverius E. , Clark R. , McCormick F. , Stampfer M. , Abularach S. and Gelmann E. P.Vimentin instead of keratin expression in a few hormone\independent breast cancers cell lines and in oncogene\transformed mammary epithelial cells . Tumor Res. , 49 , 4258 C 4263 ( 1989. ). [PubMed] [Google Scholar] 12. ) Musil L. S. , Cunningham B. A. , Edelman G. M. and Goodenough D. A.Differential phosphorylation from the gap junction protein connexin 43 in junctional communication\capable and \lacking cell lines . J. Cell Biol. , 111 , 2077 C 2088 ( 1990. ). [PMC free of charge content] [PubMed] [Google Scholar] 13. ) Ozawa M. , Baribault H. and Kemler R.The cytoplasmic area from Pitavastatin calcium ic50 the cell adhesion molecule uvomorulin associates with three independent proteins structurally related Pitavastatin calcium ic50 in different species . EMBO J. , 8 , 1711 C 1717 ( 1989. ). [PMC free article] [PubMed] [Google Scholar] 14..